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Target
Stromelysin-3
Ligand
BDBM50078938
Substrate
n/a
Meas. Tech.
ChEMBL_106454 (CHEMBL716816)
Ki
5±n/a nM
Citation
 Vassiliou, S; Mucha, A; Cuniasse, P; Georgiadis, D; Lucet-Levannier, K; Beau, F; Kannan, R; Murphy, G; Knäuper, V; Rio, MC; Basset, P; Yiotakis, A; Dive, V Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure-activity study. J Med Chem 42:2610-20 (1999) [PubMed]  Article 
Target
Name:
Stromelysin-3
Synonyms:
MMP11_MOUSE | Matrix metalloproteinase 11 | Mmp11
Type:
PROTEIN
Mol. Mass.:
55452.62
Organism:
Mus musculus
Description:
ChEMBL_106453
Residue:
492
Sequence:
MARAACLLRAISRVLLLPLPLLLLLLLLLPSPLMARARPPESHRHHPVKKGPRLLHAALPNTLTSVPASHWVPSPAGSSRPLRCGVPDLPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQMAPTSPAPTLSSQAGTDTNEIALLEPETPPDVCETSFDAVSTIRGELFFFKAGFVWRLRSGRLQPGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVHAALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRSTDWRGVPSEIDAAFQDAEGYAYFLRGHLYWKFDPVKVKVLEGFPRPVGPDFFDCAEPANTFR
  
Inhibitor
Name:
BDBM50078938
Synonyms:
(2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydrazinocarbonyl}-5-phenyl-pentyl)-{1-[(6,8-dichloro-2-oxo-2H-chromene-3-carbonyl)-amino]-2-phenyl-ethyl}-phosphinic acid | CHEMBL315046
Type:
Small organic molecule
Emp. Form.:
C41H40Cl2N5O7P
Mol. Mass.:
816.665
SMILES:
NN(C(Cc1c[nH]c2ccccc12)C(N)=O)C(=O)C(CCCc1ccccc1)CP(O)(=O)C(Cc1ccccc1)NC(=O)c1cc2cc(Cl)cc(Cl)c2oc1=O
Structure:
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