Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50524379
Substrate
n/a
Meas. Tech.
ChEMBL_1892968 (CHEMBL4394889)
IC50
<50±n/a nM
Citation
 Kumar, A; Pasam, VR; Thakur, RK; Singh, M; Singh, K; Shukla, M; Yadav, A; Dogra, S; Sona, C; Umrao, D; Jaiswal, S; Ahmad, H; Rashid, M; Singh, SK; Wahajuddin, M; Dwivedi, AK; Siddiqi, MI; Lal, J; Tripathi, RP; Yadav, PN Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity. J Med Chem 62:4638-4655 (2019) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47859.34
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-1 receptors in HEK 293 cells.
Residue:
428
Sequence:
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
  
Inhibitor
Name:
BDBM50524379
Synonyms:
CHEMBL4540275
Type:
Small organic molecule
Emp. Form.:
C30H32N4O5
Mol. Mass.:
528.5989
SMILES:
COc1ccc(c(OC)c1)-c1nc(NC(=O)c2cc3ccccc3n2CC(O)=O)ncc1CC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: