Reaction Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM50524428
Substrate
n/a
Meas. Tech.
ChEMBL_1893171 (CHEMBL4395092)
IC50
4930±n/a nM
Citation
Sunke, R; Bankala, R; Thirupataiah, B; Ramarao, EVVS; Kumar, JS; Doss, HM; Medishetti, R; Kulkarni, P; Kapavarapu, RK; Rasool, M; Mudgal, J; Mathew, JE; Shenoy, GG; Parsa, KVL; Pal, M InCl Eur J Med Chem 174:198-215 (2019) [PubMed] Article More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D
Type:
Protein
Mol. Mass.:
91092.69
Organism:
Human
Description:
Q08499
Residue:
809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
Inhibitor
Name:
BDBM50524428
Synonyms:
CHEMBL4446265
Type:
Small organic molecule
Emp. Form.:
C21H20ClN3O
Mol. Mass.:
365.856
SMILES:
CCC(C)n1cc(-c2nc3ccccc3nc2Cl)c2cc(OC)ccc12
Structure:
