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Target
Methionine aminopeptidase 2
Ligand
BDBM50524871
Substrate
n/a
Meas. Tech.
ChEMBL_1895022 (CHEMBL4397057)
IC50
50±n/a nM
Citation
 Heinrich, T; Seenisamy, J; Blume, B; Bomke, J; Calderini, M; Eckert, U; Friese-Hamim, M; Kohl, R; Lehmann, M; Leuthner, B; Musil, D; Rohdich, F; Zenke, FT Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. J Med Chem 62:5025-5039 (2019) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Human
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM50524871
Synonyms:
CHEMBL4524329
Type:
Small organic molecule
Emp. Form.:
C20H17ClFN3O4
Mol. Mass.:
417.818
SMILES:
O[C@@]1(CCN(C1=O)c1ccc2NC(=O)Cc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Structure:
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