Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50527096
Substrate
n/a
Meas. Tech.
ChEMBL_1902058 (CHEMBL4404280)
Ki
2.9±n/a nM
Citation
 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. J Med Chem 63:3317-3326 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50527096
Synonyms:
CHEMBL4558452
Type:
Small organic molecule
Emp. Form.:
C17H15ClN2O4S
Mol. Mass.:
378.83
SMILES:
CC(=O)C(=C/c1ccccc1Cl)\C(=O)Nc1ccc(cc1)S(N)(=O)=O
Structure:
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