Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50527087
Substrate
n/a
Meas. Tech.
ChEMBL_1902058 (CHEMBL4404280)
Ki
3.1±n/a nM
Citation
 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. J Med Chem 63:3317-3326 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50527087
Synonyms:
CHEMBL4450169
Type:
Small organic molecule
Emp. Form.:
C18H18N2O5S
Mol. Mass.:
374.411
SMILES:
COc1ccc(\C=C(/C(C)=O)C(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: