Reaction Details Report a problem with these data
Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50085757
Substrate
n/a
Meas. Tech.
ChEMBL_71751 (CHEMBL680273)
Ki
0.32±n/a nM
Citation
 Rivier, JE; Porter, J; Cervini, LA; Lahrichi, SL; Kirby, DA; Struthers, RS; Koerber, SC; Rivier, CL Design of monocyclic (1-3) and dicyclic (1-3/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:797-806 (2000) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50085757
Synonyms:
CHEMBL427745 | cyclo(1,1'-3)Ac-D-Asp (beta-Ala)-D-Cpa-D-Dbu-Ser-Tyr-D-Nal-Leu-Arg-Pro-D-Ala-NH2
Type:
Small organic molecule
Emp. Form.:
C71H97ClN16O15
Mol. Mass.:
1450.081
SMILES:
CCCCC1C[C@@H](NC(=O)CCNC(=O)CC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Structure:
Search PDB for entries with ligand similarity: