Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM50533342
Substrate
n/a
Meas. Tech.
ChEMBL_1925132 (CHEMBL4428204)
Ki
0.900000±n/a nM
Citation
 Zaveri, NT Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility. J Med Chem 59:7011-28 (2016) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50533342
Synonyms:
Cebranopadol | GRT-6005 | GRT6005
Type:
Small organic molecule
Emp. Form.:
C24H27FN2O
Mol. Mass.:
378.4824
SMILES:
CN(C)[C@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccc(F)cc12)c1ccccc1 |r,wU:3.2,wD:6.9,(22.98,-15.72,;21.49,-16.12,;20.4,-15.04,;21.1,-17.62,;20.33,-18.95,;18.8,-18.94,;18.04,-17.61,;18.8,-16.28,;20.34,-16.29,;17.13,-18.87,;15.59,-18.71,;14.96,-17.29,;15.87,-16.05,;17.41,-16.21,;18.04,-14.8,;16.89,-13.76,;16.89,-12.21,;15.55,-11.44,;14.22,-12.21,;12.89,-11.44,;14.22,-13.76,;15.55,-14.53,;22.63,-17.63,;23.4,-18.97,;24.94,-18.98,;25.72,-17.65,;24.94,-16.3,;23.41,-16.3,)|
Structure:
Search PDB for entries with ligand similarity: