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Target
Beta-1 adrenergic receptor
Ligand
BDBM50089479
Substrate
n/a
Meas. Tech.
ChEBML_37266
IC50
3000±n/a nM
Citation
 Biftu, T; Feng, DD; Liang, GB; Kuo, H; Qian, X; Naylor, EM; Colandrea, VJ; Candelore, MR; Cascieri, MA; Colwell, LF; Forrest, MJ; Hom, GJ; MacIntyre, DE; Stearns, RA; Strader, CD; Wyvratt, MJ; Fisher, MH; Weber, AE Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents. Bioorg Med Chem Lett 10:1431-4 (2000) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50089479
Synonyms:
CHEMBL285499 | N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-[5-(3,4,5-trifluoro-benzyl)-[1,2,4]oxadiazol-3-yl]-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C30H26F3N5O4S
Mol. Mass.:
609.619
SMILES:
O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(cc2)-c2noc(Cc3cc(F)c(F)c(F)c3)n2)cc1)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: