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Target
Kappa-type opioid receptor
Ligand
BDBM50534066
Substrate
n/a
Meas. Tech.
ChEMBL_1927697 (CHEMBL4430769)
Ki
900±n/a nM
Citation
 Ronsisvalle, S; Aricò, G; Panarello, F; Spadaro, A; Pasquinucci, L; Pappalardo, MS; Parenti, C; Ronsisvalle, N An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain. Bioorg Med Chem 24:5280-5290 (2016) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42692.90
Organism:
Rattus norvegicus (rat)
Description:
P34975
Residue:
380
Sequence:
MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
  
Inhibitor
Name:
BDBM50534066
Synonyms:
CHEMBL4562025
Type:
Small organic molecule
Emp. Form.:
C32H36N2O2
Mol. Mass.:
480.6404
SMILES:
[H][C@]12Cc3ccc(O)cc3[C@](C)(CCN1CCC(=O)N1CCc3ccccc3[C@@H]1c1ccccc1)[C@H]2C |r,THB:36:35:3.9.2:12.13.14|
Structure:
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