Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50535446
Substrate
n/a
Meas. Tech.
ChEMBL_1930712 (CHEMBL4433963)
EC50
580±n/a nM
Citation
 Wang, P; Felsing, DE; Chen, H; Raval, SR; Allen, JA; Zhou, J Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med Chem Lett 10:792-799 (2019) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50535446
Synonyms:
CHEMBL4565185
Type:
Small organic molecule
Emp. Form.:
C21H22N4O3
Mol. Mass.:
378.4244
SMILES:
Cc1nc2CCCc2c(Oc2ccc(c(C)c2)-c2c(C)c(=O)[nH]c(=O)n2C)n1 |(33.3,-46.72,;31.96,-45.95,;30.63,-46.73,;29.29,-45.96,;27.83,-46.44,;26.92,-45.2,;27.82,-43.95,;29.29,-44.42,;30.63,-43.65,;30.63,-42.11,;31.96,-41.35,;33.3,-42.12,;34.64,-41.34,;34.63,-39.79,;33.29,-39.03,;33.29,-37.49,;31.97,-39.8,;35.96,-39.02,;35.95,-37.48,;34.61,-36.72,;37.29,-36.71,;37.28,-35.17,;38.62,-37.48,;38.62,-39.02,;39.95,-39.79,;37.29,-39.79,;37.29,-41.33,;31.96,-44.42,)|
Structure:
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