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Target
D(1A) dopamine receptor
Ligand
BDBM50535453
Substrate
n/a
Meas. Tech.
ChEMBL_1930712 (CHEMBL4433963)
EC50
360±n/a nM
Citation
 Wang, P; Felsing, DE; Chen, H; Raval, SR; Allen, JA; Zhou, J Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med Chem Lett 10:792-799 (2019) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50535453
Synonyms:
CHEMBL4475239
Type:
Small organic molecule
Emp. Form.:
C22H20N4O3
Mol. Mass.:
388.4192
SMILES:
Cc1c2CCN(c2ccc1-c1c(C)c(=O)[nH]c(=O)n1C)c1nccc2occc12 |(56.94,-6.64,;56.94,-8.18,;58.27,-8.95,;59.74,-8.46,;60.66,-9.71,;59.76,-10.97,;58.28,-10.5,;56.94,-11.27,;55.61,-10.49,;55.62,-8.95,;54.29,-8.18,;54.29,-6.64,;55.62,-5.88,;52.96,-5.86,;52.96,-4.32,;51.63,-6.64,;51.63,-8.18,;50.3,-8.95,;52.96,-8.94,;52.96,-10.48,;60.24,-12.43,;61.75,-12.74,;62.23,-14.19,;61.21,-15.35,;59.7,-15.04,;58.47,-15.95,;57.22,-15.06,;57.68,-13.6,;59.21,-13.59,)|
Structure:
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