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Target
D(1A) dopamine receptor
Ligand
BDBM50523450
Substrate
n/a
Meas. Tech.
ChEMBL_1930714 (CHEMBL4433965)
EC50
1100±n/a nM
Citation
 Wang, P; Felsing, DE; Chen, H; Raval, SR; Allen, JA; Zhou, J Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med Chem Lett 10:792-799 (2019) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50523450
Synonyms:
CHEMBL4437012
Type:
Small organic molecule
Emp. Form.:
C20H17N3O2
Mol. Mass.:
331.3679
SMILES:
Cc1cnnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C |(41.44,-20.14,;42.78,-20.9,;44.1,-20.13,;45.45,-20.89,;45.45,-22.43,;44.12,-23.21,;44.13,-24.75,;42.79,-22.44,;41.46,-23.21,;41.47,-24.75,;40.13,-25.53,;38.81,-24.75,;37.47,-25.53,;37.48,-27.07,;38.81,-27.83,;38.82,-29.38,;37.48,-30.15,;36.15,-29.38,;34.67,-29.86,;33.77,-28.6,;34.68,-27.35,;36.15,-27.83,;38.79,-23.22,;40.12,-22.45,;40.11,-20.91,)|
Structure:
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