Reaction Details Report a problem with these data
Target
Polymerase acidic protein
Ligand
BDBM50508966
Substrate
n/a
Meas. Tech.
ChEMBL_1932894 (CHEMBL4478546)
IC50
13±n/a nM
Citation
 Credille, CV; Chen, Y; Cohen, SM Fragment-Based Identification of Influenza Endonuclease Inhibitors. J Med Chem 59:6444-54 (2016) [PubMed]  Article 
Target
Name:
Polymerase acidic protein
Synonyms:
Hepatitis C virus polyprotein | PA | PA/PB1 | PA_I34A1 | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2
Type:
PROTEIN
Mol. Mass.:
82573.84
Organism:
Hepatitis C virus
Description:
ChEMBL_64976
Residue:
716
Sequence:
MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
  
Inhibitor
Name:
BDBM50508966
Synonyms:
CHEMBL4452342
Type:
Small organic molecule
Emp. Form.:
C20H17ClN6O2
Mol. Mass.:
408.841
SMILES:
CN(Cc1cc(=O)c(O)cn1-c1ccc(cc1)-c1nnn[nH]1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: