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Target
Plasminogen
Ligand
BDBM50092333
Substrate
n/a
Meas. Tech.
ChEBML_155416
IC50
230±n/a nM
Citation
 Okada, Y; Tsuda, Y; Wanaka, K; Tada, M; Okamoto, U; Okamoto, S; Hijikata-Okunomiya, A; Bokonyi, G; Szende, B; Keri, G Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and HT29 cell lines. Bioorg Med Chem Lett 10:2217-21 (2001) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLG | PLMN_HUMAN | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:
Enzyme
Mol. Mass.:
90579.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
  
Inhibitor
Name:
BDBM50092333
Synonyms:
CHEMBL3084793 | Carbonic acid 4-{2-(4-acetyl-phenylcarbamoyl)-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-ethyl}-phenyl ester 2-bromo-benzyl ester
Type:
Small organic molecule
Emp. Form.:
C33H36BrN3O6
Mol. Mass.:
650.559
SMILES:
CC(=O)c1ccc(NC(=O)C(Cc2ccc(OC(=O)OCc3ccccc3Br)cc2)NC(=O)[C@H]2CC[C@H](CN)CC2)cc1 |wU:36.38,wD:33.34,(8.83,-9.49,;7.29,-9.49,;6.52,-10.82,;6.52,-8.15,;7.29,-6.82,;6.52,-5.48,;4.98,-5.48,;4.21,-4.15,;2.67,-4.15,;1.9,-5.48,;1.9,-2.82,;2.67,-1.48,;4.21,-1.48,;4.98,-2.82,;6.52,-2.82,;7.29,-1.48,;8.83,-1.48,;9.6,-2.82,;8.83,-4.15,;11.14,-2.82,;11.91,-4.15,;13.45,-4.15,;14.22,-2.82,;15.76,-2.82,;16.53,-4.15,;15.76,-5.48,;14.22,-5.48,;13.45,-6.82,;6.52,-.15,;4.98,-.15,;.36,-2.82,;-.41,-4.15,;.36,-5.48,;-1.95,-4.15,;-2.72,-2.82,;-4.26,-2.82,;-5.03,-4.15,;-6.57,-4.15,;-7.34,-2.82,;-4.26,-5.48,;-2.72,-5.48,;4.21,-6.82,;4.98,-8.15,)|
Structure:
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