Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM261794
Substrate
n/a
Meas. Tech.
ChEMBL_1935411 (CHEMBL4481170)
IC50
6.8±n/a nM
Citation
 Bäurle, S; Nagel, J; Peters, O; Bräuer, N; Ter Laak, A; Preusse, C; Rottmann, A; Heldmann, D; Bothe, U; Blume, T; Zorn, L; Walter, D; Zollner, TM; Steinmeyer, A; Langer, G Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis. J Med Chem 62:2541-2563 (2019) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM261794
Synonyms:
9-Ethyl-3-[1-(2-methoxyethyl)-5-(1H-tetrazol-5-yl)-1H-benzimidazol-2-yl]-9H-carbazole | US9708311, 45
Type:
Small organic molecule
Emp. Form.:
C25H23N7O
Mol. Mass.:
437.4964
SMILES:
CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)-c1nnn[nH]1
Structure:
Search PDB for entries with ligand similarity: