Reaction Details
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Lysophosphatidic acid receptor 1
Ligand
BDBM50539046
Substrate
n/a
Meas. Tech.
ChEMBL_1977569 (CHEMBL4610704)
EC50
1700±n/a nM
Citation
González-Gil, I; Zian, D; Vázquez-Villa, H; Hernández-Torres, G; Martínez, RF; Khiar-Fernández, N; Rivera, R; Kihara, Y; Devesa, I; Mathivanan, S; Del Valle, CR; Zambrana-Infantes, E; Puigdomenech, M; Cincilla, G; Sanchez-Martinez, M; Rodríguez de Fonseca, F; Ferrer-Montiel, AV; Chun, J; López-Vales, R; López-Rodríguez, ML; Ortega-Gutiérrez, S A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA J Med Chem 63:2372-2390 (2020) [PubMed] Article More Info.:
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
Inhibitor
Name:
BDBM50539046
Synonyms:
CHEMBL4636192
Type:
Small organic molecule
Emp. Form.:
C24H39FO6
Mol. Mass.:
442.5613
SMILES:
CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H]1CC(F)(C(O)=O)C(=O)O1 |r|
Structure:
