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Target
Lanosterol synthase
Ligand
BDBM50095597
Substrate
n/a
Meas. Tech.
ChEMBL_145019 (CHEMBL753715)
IC50
398±n/a nM
Citation
 Brown, GR; Hollinshead, DM; Stokes, ES; Waterson, D; Clarke, DS; Foubister, AJ; Glossop, SC; McTaggart, F; Mirrlees, DJ; Smith, GJ; Wood, R A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase. J Med Chem 43:4964-72 (2001) [PubMed]  Article 
Target
Name:
Lanosterol synthase
Synonyms:
LSS_RAT | Lss | Osc
Type:
PROTEIN
Mol. Mass.:
83302.12
Organism:
Rattus norvegicus
Description:
ChEMBL_12083
Residue:
733
Sequence:
MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLDTTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYPDNTLAGHI
  
Inhibitor
Name:
BDBM50095597
Synonyms:
CHEMBL359233 | [4-(4-Bromo-benzenesulfonyl)-piperazin-1-yl]-[1-(2-methyl-pyrimidin-4-yl)-piperidin-4-yl]-methanone
Type:
Small organic molecule
Emp. Form.:
C21H26BrN5O3S
Mol. Mass.:
508.432
SMILES:
Cc1nccc(n1)N1CCC(CC1)C(=O)N1CCN(CC1)S(=O)(=O)c1ccc(Br)cc1
Structure:
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