Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50542256
Substrate
n/a
Meas. Tech.
ChEMBL_1986381 (CHEMBL4619928)
IC50
406±n/a nM
Citation
 Shi, W; Wang, Y; Wu, C; Yang, F; Zheng, W; Wu, S; Liu, Y; Wang, Z; He, Y; Shen, J Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50542256
Synonyms:
CHEMBL4648027
Type:
Small organic molecule
Emp. Form.:
C22H23Cl2N5OS
Mol. Mass.:
476.422
SMILES:
Clc1cc(Cl)c2nn(CCCCN3CCN(CC3)c3cccc4sccc34)c(=O)n2c1
Structure:
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