Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50099016
Substrate
n/a
Meas. Tech.
ChEBML_895
Ki
0.800000±n/a nM
Citation
 Sabb, AL; Vogel, RL; Kelly, MG; Palmer, Y; Smith, DL; Andree, TH; Schechter, LE 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors. Bioorg Med Chem Lett 11:1069-71 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Human
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50099016
Synonyms:
CHEMBL275964 | Cyclohexanecarboxylic acid {(S)-1-benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethyl}-amide
Type:
Small organic molecule
Emp. Form.:
C22H30ClN5OS
Mol. Mass.:
448.025
SMILES:
Clc1nsnc1N1CCN(C[C@H](Cc2ccccc2)NC(=O)C2CCCCC2)CC1
Structure:
Search PDB for entries with ligand similarity: