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Target
D(4) dopamine receptor
Ligand
BDBM50099386
Substrate
n/a
Meas. Tech.
ChEBML_60988
Ki
2.3±n/a nM
Citation
 Nishimura, T; Igarashi, J; Sunagawa, M Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands. Bioorg Med Chem Lett 11:1141-4 (2001) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50099386
Synonyms:
(1-Benzyl-piperidin-4-yl)-[6-chloro-5-(4-chloro-phenylsulfanyl)-2-methyl-pyrimidin-4-yl]-amine | CHEMBL15270
Type:
Small organic molecule
Emp. Form.:
C23H24Cl2N4S
Mol. Mass.:
459.434
SMILES:
Cc1nc(Cl)c(Sc2ccc(Cl)cc2)c(NC2CCN(Cc3ccccc3)CC2)n1
Structure:
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