Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50543307
Substrate
n/a
Meas. Tech.
ChEMBL_1988879 (CHEMBL4622426)
Ki
949±n/a nM
Citation
 Greenfield, DA; Schmidt, HR; Skiba, MA; Mandler, MD; Anderson, JR; Sliz, P; Kruse, AC Virtual Screening for Ligand Discovery at the ? ACS Med Chem Lett 11:1555-1561 (2020) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Human
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50543307
Synonyms:
CHEMBL4644243
Type:
Small organic molecule
Emp. Form.:
C18H18F3N3S
Mol. Mass.:
365.416
SMILES:
Fc1ccc(CN2CCCN(C2)C(=S)Nc2cc(F)cc(F)c2)cc1
Structure:
Search PDB for entries with ligand similarity: