Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50543311
Substrate
n/a
Meas. Tech.
ChEMBL_1988879 (CHEMBL4622426)
Ki
250±n/a nM
Citation
 Greenfield, DA; Schmidt, HR; Skiba, MA; Mandler, MD; Anderson, JR; Sliz, P; Kruse, AC Virtual Screening for Ligand Discovery at the ? ACS Med Chem Lett 11:1555-1561 (2020) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Human
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50543311
Synonyms:
CHEMBL4641016
Type:
Small organic molecule
Emp. Form.:
C18H19ClFN3O
Mol. Mass.:
347.814
SMILES:
NC(=O)c1cccc(CNC2CCN(C2)c2ccc(F)c(Cl)c2)c1
Structure:
Search PDB for entries with ligand similarity: