Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50316303
Substrate
n/a
Meas. Tech.
ChEMBL_1989849 (CHEMBL4623584)
IC50
2900±n/a nM
Citation
 Golojuch, S; Kopcial, M; Strzelecka, D; Kasprzyk, R; Baran, N; Sikorski, PJ; Kowalska, J; Jemielity, J Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | IF4E_RABIT
Type:
PROTEIN
Mol. Mass.:
25047.40
Organism:
Rabbit
Description:
ChEMBL_1511842
Residue:
217
Sequence:
MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50316303
Synonyms:
((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate | CHEMBL1094974
Type:
Small organic molecule
Emp. Form.:
C11H17N5O11P2
Mol. Mass.:
457.2271
SMILES:
C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|
Structure:
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