Reaction Details Report a problem with these data
Target
Target of rapamycin complex 2 subunit MAPKAP1
Ligand
BDBM50546184
Substrate
n/a
Meas. Tech.
ChEMBL_2014679 (CHEMBL4668257)
IC50
64±n/a nM
Citation
 Borsari, C; Rageot, D; Beaufils, F; Bohnacker, T; Keles, E; Buslov, I; Melone, A; Sele, AM; Hebeisen, P; Fabbro, D; Hillmann, P; Wymann, MP Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety. ACS Med Chem Lett 10:1473-1479 (2019) [PubMed]  Article 
Target
Name:
Target of rapamycin complex 2 subunit MAPKAP1
Synonyms:
MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1
Type:
PROTEIN
Mol. Mass.:
59129.70
Organism:
Homo sapiens
Description:
ChEMBL_119716
Residue:
522
Sequence:
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
  
Inhibitor
Name:
BDBM50546184
Synonyms:
CHEMBL4758284
Type:
Small organic molecule
Emp. Form.:
C17H22F2N8O2
Mol. Mass.:
408.4058
SMILES:
C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)nc1C(F)F)N1CCOCC1 |r|
Structure:
Search PDB for entries with ligand similarity: