Reaction Details
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Target
Tyrosine-protein kinase BTK
Ligand
BDBM264139
Substrate
n/a
Meas. Tech.
ChEMBL_2019224 (CHEMBL4672802)
IC50
0.940000±n/a nM
Citation
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More Info.:
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Inhibitor
Name:
BDBM264139
Synonyms:
4-(3-(R)-(5-Chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide (14), and | US9714234, 14
Type:
Small organic molecule
Emp. Form.:
C31H25ClN4O4
Mol. Mass.:
553.008
SMILES:
Cc1c(cccc1-n1c(=O)cc2c(Cl)cccn2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O |(2.1,10.61,;1.7,9.12,;.37,9.89,;-.97,9.12,;-.97,7.58,;.37,6.81,;1.7,7.58,;3.03,6.81,;3.03,5.27,;1.7,4.5,;4.37,4.5,;5.7,5.27,;7.03,4.5,;7.03,2.96,;8.37,5.27,;8.37,6.81,;7.03,7.58,;5.7,6.81,;4.37,7.58,;4.37,9.12,;.37,11.43,;1.7,12.2,;1.7,13.74,;.37,14.51,;.37,16.05,;1.7,16.82,;-.97,16.82,;-.97,13.74,;-2.43,14.22,;-3.34,12.97,;-4.87,12.81,;-5.49,11.4,;-4.59,10.16,;-3.06,10.32,;-2.43,11.73,;-.97,12.2,;-7.03,11.4,;-8.37,10.63,;-6.64,9.92,;-7.8,12.74,)|