Reaction Details Report a problem with these data
Target
Platelet-activating factor acetylhydrolase
Ligand
BDBM50107501
Substrate
n/a
Meas. Tech.
ChEBML_101009
IC50
0.500000±n/a nM
Citation
Boyd, HF; Fell, SC; Hickey, DM; Ife, RJ; Leach, CA; Macphee, CH; Milliner, KJ; Pinto, IL; Rawlings, DA; Smith, SA; Stansfield, IG; Stanway, SJ; Theobald, CJ; Whittaker, CM Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones. Bioorg Med Chem Lett 12:51-5 (2001) [PubMed] Article
More Info.:
Target
Name:
Platelet-activating factor acetylhydrolase
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
50084.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156212
Residue:
441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
Inhibitor
Name:
BDBM50107501
Synonyms:
CHEMBL155227 | N-(4'-Chloro-biphenyl-4-ylmethyl)-2-[5-(1-ethyl-2-oxo-1,2-dihydro-pyrimidin-5-ylmethyl)-2-(4-fluoro-benzylsulfanyl)-4-oxo-4H-pyrimidin-1-yl]-N-methyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C34H31ClFN5O3S
Mol. Mass.:
644.158
SMILES:
CCn1cc(Cc2cn(CC(=O)N(C)Cc3ccc(cc3)-c3ccc(Cl)cc3)c(SCc3ccc(F)cc3)nc2=O)cnc1=O