Reaction Details Report a problem with these data
Target
Cystathionine gamma-lyase
Ligand
BDBM50548280
Substrate
n/a
Meas. Tech.
ChEMBL_2021492 (CHEMBL4675305)
IC50
142900±n/a nM
Citation
 Hu, Y; Wang, L; Han, X; Zhou, Y; Zhang, T; Wang, L; Hong, T; Zhang, W; Guo, XX; Sun, J; Qi, Y; Yu, J; Liu, H; Wu, F Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine ?-Lyase. J Med Chem 62:1677-1683 (2019) [PubMed]  Article 
Target
Name:
Cystathionine gamma-lyase
Synonyms:
CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase
Type:
Protein
Mol. Mass.:
44509.52
Organism:
Homo sapiens (Human)
Description:
P32929
Residue:
405
Sequence:
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
  
Inhibitor
Name:
BDBM50548280
Synonyms:
CHEMBL1205573
Type:
Small organic molecule
Emp. Form.:
C23H16Cl2O9S
Mol. Mass.:
539.339
SMILES:
CC1=C\C(C=C(C(O)=O)C1=O)=C(/c1cc(C)c(O)c(c1)C(O)=O)c1c(Cl)ccc(c1Cl)S(O)(=O)=O |t:1,4|
Structure:
Search PDB for entries with ligand similarity: