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Target
Mitogen-activated protein kinase kinase kinase 10
Ligand
BDBM50108299
Substrate
n/a
Meas. Tech.
ChEBML_122392
IC50
28±n/a nM
Citation
 Murakata, C; Kaneko, M; Gessner, G; Angeles, TS; Ator, MA; O'Kane, TM; McKenna, BA; Thomas, BA; Mathiasen, JR; Saporito, MS; Bozyczko-Coyne, D; Hudkins, RL Mixed lineage kinase activity of indolocarbazole analogues. Bioorg Med Chem Lett 12:147-50 (2001) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase kinase kinase 10
Synonyms:
M3K10_HUMAN | MAP3K10 | MLK2 | MST | Mitogen-activated protein kinase kinase kinase 10 | Mixed Lineage Kinase 2 (MLK2)
Type:
PROTEIN
Mol. Mass.:
103699.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1460564
Residue:
954
Sequence:
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
  
Inhibitor
Name:
BDBM50108299
Synonyms:
CHEMBL288229 | Indolocarbazole analogue
Type:
Small organic molecule
Emp. Form.:
C30H27N3O5S
Mol. Mass.:
541.617
SMILES:
CCSCc1ccc2n3c4c(c5CNC(=O)c5c5c6ccccc6n([C@H]6C[C@](O)(C(=O)OC)[C@]3(C)O6)c45)c2c1
Structure:
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