Reaction Details
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Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM50549339
Substrate
n/a
Meas. Tech.
ChEMBL_2024413 (CHEMBL4678226)
IC50
37±n/a nM
Citation
Pissot Soldermann, C; Simic, O; Renatus, M; Erbel, P; Melkko, S; Wartmann, M; Bigaud, M; Weiss, A; McSheehy, P; Endres, R; Santos, P; Blank, J; Schuffenhauer, A; Bold, G; Buschmann, N; Zoller, T; Altmann, E; Manley, PW; Dix, I; Buchdunger, E; Scesa, J; Quancard, J; Schlapbach, A; Bornancin, F; Radimerski, T; Régnier, CH Discovery of Potent, Highly Selective, and J Med Chem 63:14576-14593 (2020) [PubMed] Article More Info.:
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Homo sapiens (Human)
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
Inhibitor
Name:
BDBM50549339
Synonyms:
CHEMBL4796575
Type:
Small organic molecule
Emp. Form.:
C22H21ClN6O3
Mol. Mass.:
452.894
SMILES:
COc1ncc(NC(=O)Nc2cnc3ccc(cc3c2N2CCOC[C@@H]2C)C#N)cc1Cl |r|
Structure:
