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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50110794
Substrate
n/a
Meas. Tech.
ChEMBL_195083 (CHEMBL797537)
IC50
>200000±n/a nM
Citation
 Khandazhinskaya, AL; Shirokova, EA; Skoblov, YS; Victorova, LS; Goryunova, LY; Beabealashvilli, RS; Pronyaeva, TR; Fedyuk, NV; Zolin, VV; Pokrovsky, AG; Kukhanova, MK Carbocyclic dinucleoside polyphosphonates: interaction with HIV reverse transcriptase and antiviral activity. J Med Chem 45:1284-91 (2002) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50110794
Synonyms:
9-[4-(Dibromomethyldiphosphonyl)oxyphosphonylmethoxy)-cyclopent-2-enyl]guanine | 9-[4-(Difluoromethyldiphosphonyl)oxyphosphonylmethoxy)cyclopent-2-enyl]guanine | CHEMBL23333
Type:
Small organic molecule
Emp. Form.:
C12H16Br2N5O10P3
Mol. Mass.:
643.012
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)C1CC(OCP(O)(=O)OP(O)(=O)C(Br)(Br)P(O)(O)=O)C=C1 |c:32|
Structure:
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