Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM50551952
Substrate
n/a
Meas. Tech.
ChEMBL_2032726 (CHEMBL4686884)
Ki
1200±n/a nM
Citation
 Chen, H; Chen, Z; Zhang, Z; Li, Y; Zhang, S; Jiang, F; Wei, J; Ding, P; Zhou, H; Gu, Q; Xu, J Discovery of new LXR? agonists as glioblastoma inhibitors. Eur J Med Chem 194:0 (2020) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50551952
Synonyms:
CHEMBL4762542
Type:
Small organic molecule
Emp. Form.:
C31H32N2O7S
Mol. Mass.:
576.66
SMILES:
COC(=O)c1ccc(cc1S(C)(=O)=O)-c1cccc(c1)[C@@H]1N(CC[C@@]11C(=O)Nc2ccccc12)C(=O)OC(C)(C)C |r|
Structure:
Search PDB for entries with ligand similarity: