Reaction Details Report a problem with these data
Target
Platelet glycoprotein VI
Ligand
BDBM50552053
Substrate
n/a
Meas. Tech.
ChEMBL_2033126 (CHEMBL4687284)
IC50
21±n/a nM
Citation
 Foster, H; Wilson, C; Philippou, H; Foster, R Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis. J Med Chem 63:12213-12242 (2020) [PubMed]  Article 
Target
Name:
Platelet glycoprotein VI
Synonyms:
GP6 | GPVI | GPVI_HUMAN | Glycoprotein 6 | Platelet glycoprotein VI
Type:
PROTEIN
Mol. Mass.:
36878.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109099
Residue:
339
Sequence:
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
  
Inhibitor
Name:
BDBM50552053
Synonyms:
Glaucocalyxin A
Type:
Small organic molecule
Emp. Form.:
C20H28O4
Mol. Mass.:
332.4339
SMILES:
[H][C@@]12CC[C@]3([H])[C@]([C@@H]1O)([C@H](O)C[C@]1([H])C(C)(C)C(=O)CC[C@@]31C)C(=O)C2=C |r,THB:26:25:7:2.3.4,24:23:7:2.3.4|
Structure:
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