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Target
Endothelin receptor type B
Ligand
BDBM50112725
Substrate
n/a
Meas. Tech.
ChEMBL_63865 (CHEMBL670726)
IC50
46±n/a nM
Citation
 Ishizuka, N; Matsumura, K; Sakai, K; Fujimoto, M; Mihara, S; Yamamori, T Structure-activity relationships of a novel class of endothelin-A receptor antagonists and discovery of potent and selective receptor antagonist, 2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3-carboxylic acid (S-1255). 1. Study on structure-activity relationships and bas J Med Chem 45:2041-55 (2002) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_PIG | Endothelin receptor ET-B
Type:
PROTEIN
Mol. Mass.:
49616.89
Organism:
Sus scrofa
Description:
ChEMBL_63872
Residue:
443
Sequence:
MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSNASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50112725
Synonyms:
2-Benzo[1,3]dioxol-5-yl-4-cyclohexylmethyl-6-isopropoxy-2H-chromene-3-carboxylic acid | CHEMBL66426
Type:
Small organic molecule
Emp. Form.:
C27H30O6
Mol. Mass.:
450.5235
SMILES:
CC(C)Oc1ccc2OC(C(C(O)=O)=C(CC3CCCCC3)c2c1)c1ccc2OCOc2c1 |t:13|
Structure:
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