Reaction Details Report a problem with these data
Target
Fibroblast growth factor 14
Ligand
BDBM50554322
Substrate
n/a
Meas. Tech.
ChEMBL_2049011 (CHEMBL4703710)
Kd
7020±n/a nM
Citation
 Wang, P; Wadsworth, PA; Dvorak, NM; Singh, AK; Chen, H; Liu, Z; Zhou, R; Holthauzen, LMF; Zhou, J; Laezza, F Design, Synthesis, and Pharmacological Evaluation of Analogues Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6. J Med Chem 63:11522-11547 (2020) [PubMed]  Article 
Target
Name:
Fibroblast growth factor 14
Synonyms:
FGF-14 | FGF14 | FGF14_HUMAN | FHF-4 | FHF4 | Fibroblast growth factor 14 | Fibroblast growth factor homologous factor 4
Type:
PROTEIN
Mol. Mass.:
27725.81
Organism:
Homo sapiens
Description:
ChEMBL_120164
Residue:
247
Sequence:
MAAAIASGLIRQKRQAREQHWDRPSASRRRSSPSKNRGLCNGNLVDIFSKVRIFGLKKRRLRRQDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT
  
Inhibitor
Name:
BDBM50554322
Synonyms:
CHEMBL4787949
Type:
Small organic molecule
Emp. Form.:
C42H68N4O8
Mol. Mass.:
757.0113
SMILES:
CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)N[C@@H](C(C)C)C(=O)OC1CCCCC1 |r,TLB:22:21:24:16.18.17,22:17:24:21.23.20,THB:20:21:16:24.19.18,20:19:16:21.22.23|
Structure:
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