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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50554403
Substrate
n/a
Meas. Tech.
ChEMBL_2049583 (CHEMBL4704282)
IC50
2.0±n/a nM
Citation
 Barberis, C; Erdman, P; Czekaj, M; Fire, L; Pribish, J; Tserlin, E; Maniar, S; Batchelor, JD; Liu, J; Patel, VF; Hebert, A; Levit, M; Wang, A; Sun, F; Huang, SA Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50554403
Synonyms:
CHEMBL4750046
Type:
Small organic molecule
Emp. Form.:
C16H20ClFN4O
Mol. Mass.:
338.808
SMILES:
[H][C@@]1(CCNC[C@@H]1F)[C@@H](C)n1cc(C)c2c(Cl)cc(nc12)C(N)=O |r|
Structure:
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