Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50118470
Substrate
n/a
Meas. Tech.
ChEMBL_105275 (CHEMBL718943)
Ki
0.045±n/a nM
Citation
 Uchikawa, O; Fukatsu, K; Tokunoh, R; Kawada, M; Matsumoto, K; Imai, Y; Hinuma, S; Kato, K; Nishikawa, H; Hirai, K; Miyamoto, M; Ohkawa, S Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists. J Med Chem 45:4222-39 (2002) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50118470
Synonyms:
CHEMBL1218 | N-[2-(1,6,7,8-Tetrahydro-2H-3-oxa-as-indacen-8-yl)-ethyl]-propionamide(S)-(-)-22b | RAMELTEON | Rozerem
Type:
Small organic molecule
Emp. Form.:
C16H21NO2
Mol. Mass.:
259.3434
SMILES:
CCC(=O)NCC[C@@H]1CCc2ccc3OCCc3c12
Structure:
Search PDB for entries with ligand similarity: