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Target
Potassium voltage-gated channel subfamily KQT member 1
Ligand
BDBM50557680
Substrate
n/a
Meas. Tech.
ChEMBL_2059791 (CHEMBL4714792)
IC50
18500±n/a nM
Citation
 Griffin, AM; Kahlig, KM; Hatch, RJ; Hughes, ZA; Chapman, ML; Antonio, B; Marron, BE; Wittmann, M; Martinez-Botella, G Discovery of the First Orally Available, Selective K ACS Med Chem Lett 12:593-602 (2021) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 1
Synonyms:
KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1
Type:
PROTEIN
Mol. Mass.:
74739.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454245
Residue:
676
Sequence:
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLPTYEQLTVPRRGPDEGS
  
Inhibitor
Name:
BDBM50557680
Synonyms:
CHEMBL4741793
Type:
Small organic molecule
Emp. Form.:
C16H12F6N6O2
Mol. Mass.:
434.2959
SMILES:
C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)(F)F |r|
Structure:
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