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Target
Histamine H3 receptor
Ligand
BDBM50119727
Substrate
n/a
Meas. Tech.
ChEBML_87253
Ki
232±n/a nM
Citation
 Vasudevan, A; Conner, SE; Gentles, RG; Faghih, R; Liu, H; Dwight, W; Ireland, L; Kang, CH; Esbenshade, TA; Bennani, YL; Hancock, AA Synthesis and evaluation of potent pyrrolidine H(3) antagonists. Bioorg Med Chem Lett 12:3055-8 (2002) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50119727
Synonyms:
(S)-2-({(2S,7S)-5-[3-(4-Cyclopropanecarbonyl-phenoxy)-propyl]-2,5-diaza-bicyclo[2.2.1]heptane-2-carbonyl}-amino)-propionic acid | CHEMBL106069
Type:
Small organic molecule
Emp. Form.:
C22H29N3O5
Mol. Mass.:
415.4828
SMILES:
C[C@H](NC(=O)N1C[C@@H]2C[C@H]1CN2CCCOc1ccc(cc1)C(=O)C1CC1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: