Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50119729
Substrate
n/a
Meas. Tech.
ChEBML_87253
Ki
208±n/a nM
Citation
 Vasudevan, A; Conner, SE; Gentles, RG; Faghih, R; Liu, H; Dwight, W; Ireland, L; Kang, CH; Esbenshade, TA; Bennani, YL; Hancock, AA Synthesis and evaluation of potent pyrrolidine H(3) antagonists. Bioorg Med Chem Lett 12:3055-8 (2002) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50119729
Synonyms:
CHEMBL102853 | Cyclopropyl-(4-{3-[(1S,4S)-5-(furan-2-carbonyl)-2,5-diaza-bicyclo[2.2.1]hept-2-yl]-propoxy}-phenyl)-methanone
Type:
Small organic molecule
Emp. Form.:
C23H26N2O4
Mol. Mass.:
394.4635
SMILES:
O=C(C1CC1)c1ccc(OCCCN2C[C@@H]3C[C@H]2CN3C(=O)c2ccco2)cc1
Structure:
Search PDB for entries with ligand similarity: