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Target
Histamine H3 receptor
Ligand
BDBM50119735
Substrate
n/a
Meas. Tech.
ChEBML_87253
Ki
2.8±n/a nM
Citation
 Vasudevan, A; Conner, SE; Gentles, RG; Faghih, R; Liu, H; Dwight, W; Ireland, L; Kang, CH; Esbenshade, TA; Bennani, YL; Hancock, AA Synthesis and evaluation of potent pyrrolidine H(3) antagonists. Bioorg Med Chem Lett 12:3055-8 (2002) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50119735
Synonyms:
3-Cyano-N-{(S)-1-[3-(4-cyclopropanecarbonyl-phenoxy)-propyl]-pyrrolidin-3-yl}-benzenesulfonamide | CHEMBL101748
Type:
Small organic molecule
Emp. Form.:
C24H27N3O4S
Mol. Mass.:
453.554
SMILES:
O=C(C1CC1)c1ccc(OCCCN2CC[C@@H](C2)NS(=O)(=O)c2cccc(c2)C#N)cc1
Structure:
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