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Target
Translocator protein
Ligand
BDBM50120358
Substrate
n/a
Meas. Tech.
ChEBML_37065
Ki
98±n/a nM
Citation
 Pacofsky, GJ; Stafford, JA; Cox, RF; Cowan, JR; Dorsey, GF; Gonzales, SS; Kaldor, I; Koszalka, GW; Lovell, GG; McIntyre, MS; Tidwell, JH; Todd, D; Whitesell, G; Wiard, RP; Feldman, PL Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists. Bioorg Med Chem Lett 12:3219-22 (2002) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50120358
Synonyms:
3-((S)-8-Chloro-1-methyl-6-pyridin-2-yl-4H-3,5,10b-triaza-benzo[e]azulen-4-yl)-propionic acid methyl ester | CHEMBL322701
Type:
Small organic molecule
Emp. Form.:
C21H19ClN4O2
Mol. Mass.:
394.854
SMILES:
COC(=O)CC[C@@H]1N=C(c2ccccn2)c2cc(Cl)ccc2-n2c(C)cnc12 |t:7|
Structure:
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