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Target
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain
Ligand
BDBM50127078
Substrate
n/a
Meas. Tech.
ChEMBL_51441 (CHEMBL876699)
IC50
5400±n/a nM
Citation
 Mu, F; Hamel, E; Lee, DJ; Pryor, DE; Cushman, M Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A. J Med Chem 46:1670-82 (2003) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain
Synonyms:
Tubulin | Tubulin alpha chain /beta chain
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 51441
Components:
This complex has 2 components.
Component 1
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Component 2
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Tubulin
Type:
PROTEIN
Mol. Mass.:
9422.48
Organism:
Bos taurus
Description:
EBI_18002
Residue:
84
Sequence:
PSPQVSTAVVEPYNSILTTKHLEHSDCFMVDNEAIYDICRRNLDIERPTTRNLNRLMSQIVSSITASLRFDGALTVDLTDVQTS
  
Inhibitor
Name:
BDBM50127078
Synonyms:
5-[2-(2,5-Dihydroxy-phenyl)-vinyl]-2-hydroxy-N-phenethyl-benzamide | CHEMBL45108
Type:
Small organic molecule
Emp. Form.:
C23H21NO4
Mol. Mass.:
375.4171
SMILES:
Oc1ccc(O)c(\C=C/c2ccc(O)c(c2)C(=O)NCCc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: