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Target
Cathepsin K
Ligand
BDBM50128970
Substrate
n/a
Meas. Tech.
ChEBML_45551
IC50
280±n/a nM
Citation
 Altmann, E; Green, J; Tintelnot-Blomley, M Arylaminoethyl amides as inhibitors of the cysteine protease cathepsin K-investigating P1' substituents. Bioorg Med Chem Lett 13:1997-2001 (2003) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50128970
Synonyms:
CHEMBL62207 | {(S)-3-Methyl-1-[2-(4-phenoxy-phenylamino)-ethylcarbamoyl]-butyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C28H33N3O4
Mol. Mass.:
475.5793
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCCNc1ccc(Oc2ccccc2)cc1
Structure:
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