Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50566011
Substrate
n/a
Meas. Tech.
ChEMBL_2094369 (CHEMBL4775632)
Ki
2.0±n/a nM
Citation
 Peng, Y; Zhang, Q; Welsh, WJ Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management. J Med Chem 64:890-904 (2021) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50566011
Synonyms:
CHEMBL4790607
Type:
Small organic molecule
Emp. Form.:
C26H34N4
Mol. Mass.:
402.575
SMILES:
Cn1nc(CN2CCC(Cc3ccccc3)CC2)nc1-c1ccc(cc1)C(C)(C)C
Structure:
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