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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50133661
Substrate
n/a
Meas. Tech.
ChEBML_154208
IC50
30±n/a nM
Citation
 Desai, RC; Gratale, DF; Han, W; Koyama, H; Metzger, E; Lombardo, VK; MacNaul, KL; Doebber, TW; Berger, JP; Leung, K; Franklin, R; Moller, DE; Heck, JV; Sahoo, SP Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists. Bioorg Med Chem Lett 13:3541-4 (2003) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50133661
Synonyms:
5-{3-[3-(4-Benzo[d]isoxazol-3-yl-2-propyl-phenoxy)-propoxy]-phenyl}-thiazolidine-2,4-dione | CHEMBL1783039 | CHEMBL2037182 | CHEMBL418874
Type:
Small organic molecule
Emp. Form.:
C28H26N2O5S
Mol. Mass.:
502.581
SMILES:
CCCc1cc(ccc1OCCCOc1cccc(c1)-c1sc(=O)[nH]c1O)-c1noc2ccccc12
Structure:
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