Reaction Details Report a problem with these data
Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50098378
Substrate
n/a
Meas. Tech.
ChEMBL_69840 (CHEMBL681891)
Ki
14±n/a nM
Citation
Sanders, JM; Gómez, AO; Mao, J; Meints, GA; Van Brussel, EM; Burzynska, A; Kafarski, P; González-Pacanowska, D; Oldfield, E 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem 46:5171-83 (2003) [PubMed] Article
More Info.:
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Human
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Inhibitor
Name:
BDBM50098378
Synonyms:
(1-Hydroxy-1-phosphono-2-pyridin-2-yl-ethyl)-phosphonic acid | 1-hydroxy-2-(pyridin-2-yl)ethane-1,1-diyldiphosphonic acid | 2-(2-Hydroxy-2,2-bis-phosphono-ethyl)-pyridinium | 2-(2-pyridyl)-1-hydroxy-ethane-1,1-bisphosphonate | CHEMBL434024
Type:
Small organic molecule
Emp. Form.:
C7H11NO7P2
Mol. Mass.:
283.1123
SMILES:
OC(Cc1ccccn1)(P(O)(O)=O)P(O)(O)=O