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Target
Serine/threonine-protein kinase 16
Ligand
BDBM50573483
Substrate
n/a
Meas. Tech.
ChEMBL_2119602 (CHEMBL4828668)
IC50
107±n/a nM
Citation
 Hatcher, JM; Vatsan, PS; Wang, E; Jiang, J; Gray, NS Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett 12:1689-1693 (2021) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 16
Synonyms:
MPSK1 | PKL12 | STK16 | STK16_HUMAN | Serine/threonine-protein kinase 16 | TSF1 | Tyrosine-protein kinase STK16 (STK16)
Type:
Protein
Mol. Mass.:
34659.07
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
305
Sequence:
MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQHTTQI
  
Inhibitor
Name:
BDBM50573483
Synonyms:
CHEMBL4877883
Type:
Small organic molecule
Emp. Form.:
C22H22ClN7O
Mol. Mass.:
435.909
SMILES:
Cn1ncc2cc(ccc12)-c1cnc2[nH]nc(Cl)c2c1N1CCC2(CCNC2=O)CC1
Structure:
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