Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50574193
Substrate
n/a
Meas. Tech.
ChEMBL_2121954 (CHEMBL4831101)
Ki
3.0±n/a nM
Citation
 Wichur, T; Gody?, J; Góral, I; Latacz, G; Bucki, A; Siwek, A; G?uch-Lutwin, M; Mordyl, B; ?niecikowska, J; Walczak, M; Knez, D; Juki?, M; Sa?at, K; Gobec, S; Ko?aczkowski, M; Malawska, B; Brazzolotto, X; Wi?ckowska, A Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT Eur J Med Chem 225:0 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50574193
Synonyms:
CHEMBL4863037
Type:
Small organic molecule
Emp. Form.:
C22H21N3O3S
Mol. Mass.:
407.485
SMILES:
O=S(=O)(c1ccccc1)n1ccc2c(OCCNCc3ccncc3)cccc12
Structure:
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