Reaction Details Report a problem with these data
Target
Cyclin-C
Ligand
BDBM50189415
Substrate
n/a
Meas. Tech.
ChEMBL_2122576 (CHEMBL4831809)
IC50
0.900000±n/a nM
Citation
 Zhang, H; Jing, L; Liu, M; Goto, M; Lai, F; Liu, X; Sheng, L; Yang, Y; Yang, Y; Li, Y; Chen, X; Lee, KH; Xiao, Z Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors. Eur J Med Chem 223:0 (2021) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50189415
Synonyms:
CHEMBL3828637
Type:
Small organic molecule
Emp. Form.:
C18H16N4O3S
Mol. Mass.:
368.41
SMILES:
CNC(=O)c1ccc2cncc(-c3ccc4N(C)S(=O)(=O)Cc4c3)c2n1
Structure:
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